Neural Tube Development MCQs Development of Neural Tube – MCQs 1. The neural tube is derived from which germ layer? Mesoderm Endoderm Ectoderm Neural crest 2. Neurulation begins approximately on which day of development? Day 10 Day 14 Day 18 Day 28 3. Fusion of neural folds begins in which region? Cranial region Caudal region Cervical region Lumbar region 4. Anterior neuropore normally closes on: Day 21 Day 23 Day 25 Day 30 5. Failure of anterior neuropore closure results in: Spina bifida Anencephaly Meningocele Syringomyelia 6. Secondary neurulation contributes to formation of: Cerebral hemispheres Brainstem Caudal spinal cord Thalamus 7. Neural crest cells arise from: Roof plate Neural folds Floor plate Basal plate 8. The sulcus limitans separates: Roof and floor plates Gray and white matter Alar and basal plates Neural tube and notochord 9. Motor neurons develop from: Alar plate Roof plate Basal plate Neural crest 10. Sensory neurons of spinal cord develop from: Basal plate Alar plate Floor plate Notochord 11. Which vitamin deficiency increases neural tube defect risk? Vitamin B12 Vitamin D Folic acid Vitamin A 12. Central canal of spinal cord develops from: Neural crest Mantle layer Lumen of neural tube Mesoderm 13. Mantle layer of neural tube forms: White matter Gray matter Ependyma Pia mater 14. Posterior neuropore normally closes by: Day 23 Day 25 Day 27 Day 35 15. Spina bifida occulta results from failure of: Neural tube closure Vertebral arch formation Notochord regression Alar plate development Submit